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HCR™ Gold RNA-FISH/IF

Unified multiplex, quantitative, high-resolution RNA and protein imaging
Combine the game-changing performance and flexibility of HCR™ Gold RNA-FISH and HCR™ Gold IF with 1-step quantitative signal amplification for 10 RNA and/or protein targets simultaneously

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Simple Robust Protocols
HCR™ Gold RNA-FISH/IF protocols are simple, robust, and enzyme-free, requiring only 3 stages (antibody binding to protein targets, probe hybridization to RNA targets, amplification) independent of the number of RNA and protein targets

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Safety Data Sheets

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HCR™ Gold RNA-FISH/IF

1-step quantitative signal amplification for 10 RNA and/or protein targets simultaneously

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Straightforward Multiplexing

HCR™ Gold RNA-FISH/IF enables straightforward multiplexing using 1-step quantitative signal amplification for 10 RNA and/or protein targets simultaneously.

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Breakthrough Flexibility

Whether your RNA target is already in our Infinite Catalog or just joining it, HCR™ HiFi Probes for any organism across the tree of life are designed by the MI Team using MI’s proprietary probe design process with no design fee.​ For protein targets, use the breakthrough HCR™ HiFi Encoder to robustly encode best-in-class quantitative signal amplification to your favorite 1º antibodies (same host species/isotype for each target protein if desired).

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Simultaneous Quantitative High-Resolution RNA and Protein Imaging

HCR™ Gold RNA-FISH/IF enables RNA and protein relative quantitation with subcellular resolution in the anatomical context of highly autofluorescent samples.

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Straightforward Multiplexing

1-step quantitative HCR™ Gold signal amplification for 10 RNA and/or protein targets simultaneously

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Quantitative RNA/Protein Imaging

RNA and protein relative quantitation with subcellular resolution in the anatomical context of highly autofluorescent samples

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Read-Out/Read-In

Bidirectional quantitative RNA and protein discovery in an anatomical context

Getting started?

For multiplex quantitative HCR™ Gold RNA-FISH/IF: 

 ✓ order one HCR™ Gold RNA-FISH kit per target RNA

 ✓ use your own favorite 1º antibody for each target protein (same host species/isotype for each target protein if desired)

 ✓ order one HCR™ Gold IF kit per target protein (select a different HCR™ HiFi Encoder for each target protein)

 ✓ select a different HCR™ Gold Amplifier for each target RNA or protein

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